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YD23

Product ID: TAC04173

Purity: 98%+

Product Unit Size	Stock	Prize
10mg	In stock	＄998.00
25mg	In stock	inquiry
50mg	In stock	inquiry
100mg	In stock	inquiry
Bulk Size	Bulk Discount

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COA HNMR HPLC

Description Product Info Shipping and Storage References

Description

YD23 is a SMARCA2 PROTAC. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. Moreover, YD23 decreases chromatin accessibility at enhancers of a number of genes including cell cycle and cell growth regulatory genes. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells mechanistically^[1]^[2].

Product Info

Solubility	DMSO : 125 mg/mL (279.06 mM; ultrasonic and warming and heat to 60°C)
Appearance	Solid powder.Please contact us for more accurate information.

Shipping and Storage

Store Temp	Room temperature in continental US; may vary elsewhere.
Ship Temp	Powder：3 years -20°C。In solvent：1 years -80°C

References

[1]. Kotagiri S, et al. Novel SMARCA2 degrading bifunctional molecules as therapeutics in SMARCA4 mutant lung cancer[J]. Cancer Research, 2023, 83(7_Supplement): 1138-1138.

[2]. Kotagiri S, et al. Enhancer reprogramming by novel SMARCA2 degrading PROTACs underlies therapeutic utility in SMARCA4 mutant tumors[J]. Cancer Research, 2023, 83(7_Supplement): 6289-6289.

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